منابع مشابه
Revisiting neural stem cell identity.
T he discovery of neural stem cells (NSCs) in the adult mammalian central nervous system (CNS) has dramatically changed our view on the regenerative capacity of this organ (1, 2). We now realize that the adult brain, including humans, retains the ability to replenish its cellular constituents, neurons and glia, although the extent is very limited compared with lower vertebrates (2). Cell turnov...
متن کاملHow Sox2 maintains neural stem cell identity.
The transcription factor Sox2 [SRY (sex-determining region Y)-box 2] is expressed at the earliest developmental stages in the nervous system and functions as a marker protein for neural development. Sox2 is found in embryonic neural stem cells as well as in virtually all adult neural stem cells of the subventricular region and the subgranular zone of the hippocampus. Gain-of-function and loss-o...
متن کاملMaintaining neural stem cell identity in the brain
In the developing fruit fly brain, a protein called Trithorax increases the number of neural cells produced from a single stem cell, in part by regulating the transcription of the target genes buttonhead and pointed.
متن کاملP70: Produce Neural Stem Cell from Neurosphere of Rat Adipose Derived Stem Cell
لطفاً به چکیده انگلیسی مراجعه شود.
متن کاملCell Lineage and Regional Identity of Cultured Spinal Cord Neural Stem Cells and Comparison to Brain-Derived Neural Stem Cells
Neural stem cells (NSCs) can be isolated from different regions of the central nervous system. There has been controversy whether regional differences amongst stem and progenitor cells are cell intrinsic and whether these differences are maintained during expansion in culture. The identification of inherent regional differences has important implications for the use of these cells in neural rep...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2008
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0711637105